Inhibition of peptide aggregation by means of enzymatic phosphorylation

• Kristin Folmert,
• Malgorzata Broncel,
• Hans v. Berlepsch,
• Christopher H. Ullrich,
• Mary-Ann Siegert and
• Beate Koksch

Beilstein J. Org. Chem. 2016, 12, 2462–2470, doi:10.3762/bjoc.12.240

• ; peptide phosphorylation; protein folding; Introduction Amyloid fibrils are one of the most important and studied self-assembled materials in nature. A wide range of peptides and proteins with various primary sequences and functions are able to form these wel organized and highly stable aggregates under